Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site
نویسندگان
چکیده
منابع مشابه
Rheb and Rags come together at the lysosome to activate mTORC1.
mTORC1 (mammalian target of rampamycin complex 1) is a highly conserved protein complex regulating cell growth and metabolism via its kinase mTOR (mammalian target of rapamycin). The activity of mTOR is under the control of various GTPases, of which Rheb and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases local...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2017
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.208017